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Recruiting NCT07629349

Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression

Conditions: Dementia With Lewy Bodies (DLB), Mild Cognitive Impairment (MCI), Cognitively Unimpaired, Other Dementias

Sex: All

Healthy volunteers: Yes

Enrollment: 600

Sponsor: Karolinska Institutet

Location: Karolinska University Hospital Stockholm

Summary

The goal of this observational study is to improve the detection of dementia with Lewy bodies (DLB) and its prodromal phases, as well as advancing our current understanding of biological mechanisms and therapeutic options. The data is acquired at cognitive clinics in Stockholm (Sweden) and combined with national and international data to increase statistical power, representativeness and replication of results. Participants undergo collection of clinical assessments, neuroimaging and fluid biomarkers.

Eligibility Criteria

Inclusion Criteria: * At least one core clinical feature of dementia with Lewy bodies such as visual hallucinations, parkinsonism, cognitive fluctuations, or probable REM sleep behaviour disorder. Exclusion Criteria: * Causes of cognitive impairment other than those related to dementia or MCI. Current or pass drug use.

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07629349). StuddyBuddy aggregates publicly available trial information.