Relationship Between Periodontal Inflammation Severity and Pan-Immune System Inflammation Value

This cross-sectional observational study aims to evaluate the relationship between periodontal inflammation severity and the Pan-Immune-Inflammation Value (PIV) in systemically healthy adults. A total of 160 participants will be recruited from the Department of Periodontology, Faculty of Dentistry, Bolu Abant Izzet Baysal University. Clinical periodontal parameters and Periodontal Inflamed Surface Area (PISA) will be recorded, and their association with PIV calculated from complete blood count parameters will be analyzed.

Inclusion Criteria: * Age 18 years and older * Systemically healthy individuals * Complete blood count performed within the previous 3 months * Diagnosis of periodontal health, gingivitis, or Stage III-IV periodontitis according to the 2017 World Workshop Classification of Periodontal and Peri-Implant Diseases and Conditions * Willingness to provide written informed consent Exclusion Criteria: * Pregnancy or lactation- History of systemic diseases that may affect periodontal tissues * Use of antibiotics or anti-inflammatory drugs within the previous 3 months * Periodontal treatment within the previous 6 months * Presence of infectious diseases such as HIV, hepatitis B, or tuberculosis