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Recruiting
NCT07622667
Correlation Analysis of Gene Characteristics of Malignant Tumors With Prognosis
Conditions: Malignant Tumors
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Enrollment: 500
Sponsor: Nanfang Hospital, Southern Medical University
Location: Nanfang Hospital, Southern Medical University Guangzhou Guangdong
Summary
This study is a single-center observational investigation aimed at systematically exploring the key molecular features influencing the prognosis of malignant tumors by integrating multidimensional clinical information with multi-omics molecular data. The goal is to provide a critical scientific basis for constructing precise prognostic prediction models, identifying potential therapeutic targets, and optimizing clinical treatment strategies. The study plans to consecutively enroll adult patients with histologically confirmed malignant tumors who received antitumor therapy at our hospital between January 2017 and December 2025. Clinical data (including demographic characteristics, tumor pathology information, treatment histories, and survival follow-up data) will be systematically collected from electronic medical records. Additionally, tumor tissue or blood samples will be obtained from the patients for sequencing, staining, ELISA, drug sensitivity testing, and flow cytometry analysis to comprehensively characterize the genomic features, immune microenvironment, and cellular heterogeneity of the tumors.
Eligibility Criteria
Inclusion Criteria:
1. Voluntarily sign the informed consent form.
2. Treated at Nanfang Hospital, Southern Medical University between January 2017 and December 2025.
3. Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2.
4. Availability of surplus routinely discarded clinical tumor tissue samples (biopsy specimens or pathological sections) or blood samples for assays such as sequencing, staining, ELISA, drug sensitivity testing, and flow cytometry.
Exclusion Criteria:Patients deemed by the investigator to be unsuitable for participation in this study.
Source: ClinicalTrials.gov (NCT07622667). StuddyBuddy aggregates publicly available trial information.
