The Effect of Exercise on Cognitive Functions in Individuals With Systemic Lupus Erythematosus

Study Objective: To examine the effect of aerobic exercise on disease activity and cognitive functions in patients diagnosed with SLE. Study Goals: 1. To conduct comprehensive pre- and post-treatment (after 12 weeks) evaluations of SLE patients included in the study, and to determine their disease activity and cognitive levels. 2. To apply aerobic exercise to SLE patients for three months. 3. To analyze the effects of the aerobic exercise program on disease activity and cognitive functions.

Inclusion Criteria: * Having been diagnosed with SLE at least one year prior according to the American Rheumatology Association (ACR) diagnostic criteria * Being between 25-65 years of age * Not having received a neuropsychiatric diagnosis * Having medication adjusted and being on stable medication for 3 months * Not being involved in a regular exercise program * Having a Mini Mental Test score lower than 26. Exclusion Criteria: * History of secondary rheumatic disease * Presence of active acute or chronic infection, * Body mass index (BMI) ≥ 30 kg/m2, * Acute renal failure, * Cardiac and pulmonary involvement, * Presence of musculoskeletal and joint disorders that prevent exercise testing, * Pregnancy