Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration

This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar region. Thirty patients requiring extraction and immediate implant placement will be randomly allocated into two groups. Clinical and radiographic outcomes including implant stability, peri-implant probing depth, modified bleeding index, marginal bone loss, buccal bone thickness, and bone density will be evaluated over a 9-month follow-up period.

Inclusion Criteria: * Age above 20 years * Non-restorable maxillary premolar teeth * Candidates for immediate implant placement * Intact socket walls * Jumping gap \>2 mm * Non-smokers or light smokers * No acute infection * Adequate bone for primary stability Exclusion Criteria: * Heavy smokers * Bruxism or clenching * Uncontrolled systemic disease * Chemotherapy/radiotherapy * Immunocompromised patients