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Completed
NCT07567924
Comparison Between Pregabalin and Acetaminophen for the Treatment of Post-Mastectomy Pain Syndrome
Conditions: Post Mastectomy Pain Syndrome
Sex: Female
Healthy volunteers: No
Phase: PHASE4
Enrollment: 158
Sponsor: Subas Ali
Location: Sindh Institute of urology and Transplantation Karachi
Summary
The goal of this trial is to learn if Pregabalin is better than Acetaminophen in pain management of patients with Post-Mastectomy pain Syndrome, which is defined as pain in the scar, chest wall, shoulder after undergoing mastectomy or breast-conservation (BCS). It could be burning, stabbing, shooting pain or pins-and-needle sensation.
Participants will:
* Take their prescribed allotted medicine for 14 days.
* Will visit the clinic at 2 and 6 week interval for assessment.
Eligibility Criteria
Inclusion Criteria:
* All diagnosed cases of post mastectomy pain syndrome
* Patients developing radiation dermatitis grade 0 and 1
Exclusion Criteria:
* Patient undergoing toilet mastectomy
* Patient developing radiation dermatitis grade 2, 3 and 4
* Patients with convulsions
* Patients with known pregabalin hypersensitivity (lightheadedness , sedation , double vision ,increase in bodyweight and imbalance)
* Patients with known acetaminophen hypersensitivity (urticaria, bronchospasm, anaphylaxis)
* Patients with renal failure
* Patients with hepatic dysfunction/ hepatic disease
* Patients with prior use of pregabalin due to chronic pain conditions within 3 months
* Pregnant or lactating
* Neuropsychiatric disorders
Source: ClinicalTrials.gov (NCT07567924). StuddyBuddy aggregates publicly available trial information.