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NCT07565207
Effect of aiTBS on Intrinsic Spectral Dynamics and Task Performance
Conditions: Brain Plasticity
Sex: All
Ages: 18 Years – 50 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 80
Sponsor: University of Pennsylvania
Summary
Aim 1: Measure local shifts in cortical spectral dynamics following aiTBS. Aim 2: Measure network-specific shifts in task performance following aiTBS. Exploratory aim: Evaluate changes to resting state spectral dynamics in absence of stimulation after aiTBS.
Eligibility Criteria
Inclusion Criteria:
* Able to give their consent
* Right-handed or ambidextrous
Exclusion Criteria:
* Non-english speaking
* Current or past non-anxiety-related psychiatric comorbidity.
* Active or history of active suicidal ideation
* Alcohol/drug problems in the past year or lifetime alcohol or drug dependence
* Medications that act on the central nervous system
* History of seizure
* History of epilepsy
* Increased risk of seizure for any reason
* Pregnancy, or positive pregnancy test
* Any medical (e.g., stroke, breathing problems, motion disorders) or neurological (e.g., a significant brain injury or brain infection history that increases seizure risk) condition that increases risk for fMRI or TMS (Protocol will follow recommendations from Rossi et al. 2021 doi:10.1016/j.clinph.2020.10.003)
* Any metal in their body which would make having an MRI scan unsafe
* Any sort of medical implants
* Hearing loss
* Claustrophobia
* orthostatic hypotension
Source: ClinicalTrials.gov (NCT07565207). StuddyBuddy aggregates publicly available trial information.