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NCT07565194
Arousal-related Memory Following Theta Burst Stimulation.
Conditions: Anxiety
Sex: All
Ages: 18 Years – 50 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 120
Sponsor: University of Pennsylvania
Summary
Aim 1: Active cTBS to IPS will disrupt arousal-dependent temporal memory, reflected in reduced relative order discrimination accuracy and expanded temporal distance estimates, relative to sham.
Aim 2: Active iTBS to IPS will enhance arousal-dependent temporal memory, reflected in improved relative order discrimination accuracy and compressed temporal distance estimates, relative to sham.
Aim 3: Baseline physiological arousal, trait anxiety (STAI), Beck Anxiety Inventory (BAI), trauma symptoms (PCL-5), and individualized E-field strength will predict the magnitude of TBS-induced behavioral changes in temporal memory.
Eligibility Criteria
Inclusion Criteria:
* Able to provide informed consent
* Right-handed (to ensure consistency in motor threshold determination)
Exclusion Criteria:
* Non-English speaking
* Significant medical problems
* Current or past psychiatric disorder
* Active or history of suicidal ideation
* Alcohol or drug problems in the past year, or lifetime alcohol or drug dependence
* Medications affecting the central nervous system
* History of seizure, epilepsy, or other neurological problems
* Any increased risk for seizure
* Pregnancy
* Medical conditions that increase risk for fMRI or TMS
* Metal in the body that makes MRI unsafe
* Medical implants
* Claustrophobia
* Orthostatic hypotension
Source: ClinicalTrials.gov (NCT07565194). StuddyBuddy aggregates publicly available trial information.