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Not Yet Recruiting NCT07565194

Arousal-related Memory Following Theta Burst Stimulation.

Conditions: Anxiety

Sex: All
Ages: 18 Years – 50 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 120
Sponsor: University of Pennsylvania

Summary

Aim 1: Active cTBS to IPS will disrupt arousal-dependent temporal memory, reflected in reduced relative order discrimination accuracy and expanded temporal distance estimates, relative to sham. Aim 2: Active iTBS to IPS will enhance arousal-dependent temporal memory, reflected in improved relative order discrimination accuracy and compressed temporal distance estimates, relative to sham. Aim 3: Baseline physiological arousal, trait anxiety (STAI), Beck Anxiety Inventory (BAI), trauma symptoms (PCL-5), and individualized E-field strength will predict the magnitude of TBS-induced behavioral changes in temporal memory.

Eligibility Criteria

Inclusion Criteria: * Able to provide informed consent * Right-handed (to ensure consistency in motor threshold determination) Exclusion Criteria: * Non-English speaking * Significant medical problems * Current or past psychiatric disorder * Active or history of suicidal ideation * Alcohol or drug problems in the past year, or lifetime alcohol or drug dependence * Medications affecting the central nervous system * History of seizure, epilepsy, or other neurological problems * Any increased risk for seizure * Pregnancy * Medical conditions that increase risk for fMRI or TMS * Metal in the body that makes MRI unsafe * Medical implants * Claustrophobia * Orthostatic hypotension

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07565194). StuddyBuddy aggregates publicly available trial information.