Fecal Microbiome Signature of Multi-Strain Probiotics Supplementation in Children and Adolescents With Inflammatory Bowel Disease

In this study the intestinal microbiome and metabolic profiles of patients with inflammatory bowel disease will be determined upon probiotic intervention.

Inclusion Criteria: * Signed informed consent * Diagnosis of inflammatory bowel disease according to actual guidelines (Porto Criteria) * General good health * Ability to understand and follow study procedures and understand informed consent * Age 5 -18 years * No probiotic therapy 4 weeks before entering into the study. Exclusion Criteria: * Participation in other clinical studies interfering with study procedures. * Inability or contraindications to undergo the investigated intervention * Severe or acute flare of disease (for UC PUCAI score ≥35, for CD wPCDAI \>40) * Treatment escalation within last 4 weeks for uncontrolled disease. * Antibiotic or probiotic therapy within the last 4 weeks.