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Completed
NCT07527481
Nortriptyline and the Risk of Serious Adverse Events
Conditions: Chronic Kidney Disease
Sex: All
Ages: 66 Years – N/A
Healthy volunteers: No
Enrollment: 5000
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Summary
This is a population-based retrospective, new-user, active comparator cohort study assessing whether initiating a new outpatient prescription of high-dose nortriptyline (\>10-150 mg/day), compared with low-dose (10 mg/day), is associated with an increased 30-day risk of serious adverse events among older adults with low kidney function (estimated glomerular filtration rate \[eGFR\] \
Eligibility Criteria
Inclusion Criteria:
* The cohort will include all older adults (≥66 years) with an eGFR \
Source: ClinicalTrials.gov (NCT07527481). StuddyBuddy aggregates publicly available trial information.
