Nanopulse Laser Therapy

The purpose of this study is to evaluate the safety and effectiveness of a novel noninvasive therapy, Nanopulse Laser Therapy (NPLT), to improve recovery following traumatic brain injury (TBI).

Inclusion Criteria: * Adults aged 18 years or older at the time of enrollment * Confirmed diagnosis of moderate to severe TBI (clinical assessment and radiographic evidence) * Admission to the neurosurgical or neurocritical care service with anticipated need for intracranial monitoring (e.g., microdialysis, ICP probe) * Able to initiate treatment within 48 hours of admission * Informed consent obtained from patient or legally authorized representative Exclusion Criteria: * Patients younger than 18 years of age * Known or suspected pregnancy (verified via urine pregnancy test for females of childbearing age) * Incarcerated individuals or prisoners * Patients with pre-existing implanted cranial devices (e.g., deep brain stimulators) that may interfere with NPLT * Patients with severe scalp injury or open wounds at intended treatment site * Known allergy or hypersensitivity to adhesives or device components