Association Between Intraoperative Mean Arterial Pressure Variability and Postoperative Fatigue in Patients Undergoing Laparoscopic Abdominal Surgery

This prospective cohort study aims to investigate the relationship between intraoperative mean arterial pressure (MAP) variability and postoperative fatigue syndrome (POFS) in elderly patients (≥18 years) undergoing laparoscopic abdominal surgery. The main research question is: Does the degree of intraoperative MAP fluctuation correlate with postoperative fatigue in elderly patients? Eligible patients scheduled for elective laparoscopic abdominal surgery under general anesthesia will have their intraoperative blood pressure variability recorded (generalized average real variability, G-ARV), and postoperative fatigue and recovery will be assessed on postoperative days 1, 3, and 7 using the Christensen fatigue scale.

Inclusion Criteria: 1. Age ≥ 18 years; 2. ASA physical status I-III; 3. Scheduled for elective laparoscopic abdominal surgery under general anesthesia. Exclusion Criteria: 1. Severe cardiac, hepatic, or renal insufficiency, or major neurological or psychiatric disorders; 2. Known allergy to drugs used during the study; 3. Participation in other clinical trials within the past 3 months; 4. Unable to complete the required questionnaires or assessments; 5. Surgery duration \< 60 minutes.