Microbiome-Focused Food Supplement for Evaporative Dry Eye Due to Meibomian Gland Dysfunction

Conditions: Dry Eye, Evaporative Dry Eye Disease, Meibomian Gland Dysfunction (Disorder)

Sex: All

Ages: 18 Years – 65 Years

Healthy volunteers: No

Phase: NA

Enrollment: 130

Sponsor: Varol TUNALI

Location: T.C. İstanbul Prof. Dr. Cemil Taşcıoğlu Şehir Hastanesi Istanbul

Summary

Dry eye disease (DED) is a common chronic condition characterized by ocular surface discomfort and tear film instability. Evaporative DED associated with meibomian gland dysfunction (MGD) is a frequent phenotype and is often driven by inflammatory mechanisms. This randomized, double-blind, placebo-controlled trial evaluates whether an oral microbiome-focused food supplement improves dry eye symptoms and objective clinical signs compared with placebo over 8 weeks in adults with moderate evaporative DED due to MGD.

Eligibility Criteria

Incluison criteria: 1. Adults aged 18-65 years. 2. Participants were required to meet all of the following criteria: * Presence of dry eye symptoms, defined as an OSDI-6 summed score ≥4 at baseline. * Objective evidence of tear film homeostasis loss in at least one eye, defined by at least one of the following: A: Non-invasive tear break-up time (NIBUT) \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07453212). StuddyBuddy aggregates publicly available trial information.