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NCT07447063
The Impact of Dietary Salt on the Severity of Eczema
Conditions: Eczema, Atopic Dermatitis
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: Yes
Phase: PHASE4
Enrollment: 40
Sponsor: University of California, San Francisco
Location: San Francisco VA Medical Center San Francisco California
Summary
The goal of this clinical trial is to evaluate the feasibility of low-sodium diet to improve eczema severity. The main questions it aims to answer are:
* Does a low-sodium diet improve eczema severity?
* How does a low-sodium diet impact skin sodium concentration?
* Is skin sodium concentration associated with eczema severity?
Researchers will ask all participant to follow a low-sodium diet, then compare sodium tablets to a placebo (a look-alike substance that contains no drug) to specifically examine the impact of altering sodium intake.
Participants will:
* Follow a low-salt diet for the duration of the 24-week study
* Take sodium chloride tablets every day for 5 weeks followed by a placebo every day for 5 weeks after a 2-week washout period, or vice versa
* Complete up to 4 virtual check-in visits
* Visit the clinic 4 times to answer questionnaires, provide bio samples, complete dietary recalls, and undergo non-contrast sodium MRI
Eligibility Criteria
Inclusion Criteria:
* Participants ages 18 years
* Willing and able to undergo non-contrast MRI.
Exclusion Criteria:
* Contraindications to MRI (such as cardiac pacemakers, claustrophobia, non-compatible intracranial vascular clips, IUDs, or other implants)
* A cardiac event in the past 6 months
* Impaired function of the liver or kidney (glomerular filtration rate \
Source: ClinicalTrials.gov (NCT07447063). StuddyBuddy aggregates publicly available trial information.