Evaluation of Serum TRACP-5b, BALP, and 25-Hydroxyvitamin D3 Levels in Stage III Periodontitis Patients

Periodontitis is a chronic inflammatory disease characterized by the progressive destruction of the supporting tissues of the teeth. Non-surgical periodontal therapy is the first-line treatment approach and aims to control inflammation and prevent further tissue breakdown. The aim of this interventional clinical study is to evaluate the effects of non-surgical periodontal therapy on serum levels of tartrate-resistant acid phosphatase 5b (TRACP-5b), bone alkaline phosphatase (BALP), and 25-hydroxyvitamin D3 in patients diagnosed with Stage III periodontitis. Patients with Stage III periodontitis will receive non-surgical periodontal therapy consisting of scaling and root planing. Clinical periodontal parameters and blood samples will be collected at baseline and after treatment. Changes in serum biomarker levels before and after therapy will be analyzed to assess the relationship between periodontal treatment and bone metabolism-related biomarkers. The findings of this study are expected to contribute to a better understanding of the systemic biochemical response to periodontal therapy in patients with advanced periodontitis.

Inclusion Criteria: * Adults aged 18 to 65 years * Diagnosed with Stage III periodontitis according to the current periodontal classification * Systemically healthy individuals * Presence of at least 20 natural teeth * Willingness to participate in the study and provide written informed consent Exclusion Criteria: * Presence of systemic diseases that may affect periodontal status or bone metabolism * Use of antibiotics, anti-inflammatory drugs, or medications affecting bone metabolism within the last 3 months * Pregnancy or lactation * Current smokers or history of smoking * Previous periodontal treatment within the last 6 months