SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers

Sex: All

Ages: 18 Years – 50 Years

Healthy volunteers: Yes

Phase: PHASE4

Enrollment: 20

Sponsor: Duke University

Summary

The SPARK Study evaluates changes in peripheral sympathetic vasomotor activity following a targeted, ultrasound-guided periarterial sympathetic block of the distal radial artery in healthy volunteers. Autonomic reactivity will be assessed before and after the block using digit-specific pulse-amplitude index and infrared thermography during standardized cold pressor testing.

Eligibility Criteria

Inclusion Criteria: * Age 18-50 years * ASA physical status I-II * Able to understand and provide informed consent * Able to comply with study procedures and follow-up * Two hands with 5 intact digits and no significant upper extremity injury Exclusion Criteria: * Allergy to lidocaine or similar anesthetics * Allergy to adhesives or ultrasound gel * Neuromuscular, autonomic, or major vascular disorders affecting upper extremities * Peripheral neuropathy * Raynaud's phenomenon or digital ischemia * Coagulopathy or anticoagulation * Active skin infection near block site * Pregnancy * BMI \> 35 kg/m² * Inability to tolerate cold exposure * Any condition interfering with study conduct

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07429292). StuddyBuddy aggregates publicly available trial information.