Prospective Evaluation of New Metrics to Assess Cardiovascular Remodeling in Obstructive Sleep Apnea

Conditions: Obstructive Sleep Apnea, Cardiovascular (CV) Risk

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Enrollment: 270

Sponsor: University Hospital, Antwerp

Location: Antwerp University Hospital Antwerp

Summary

The goal of this prospective study is to gain insight into the endophenotypic variation in OSA, with a focus on the underlying pathophysiological traits and the cardiovascular alterations associated with the condition. To capture the variability in OSA endophenotypes, novel metrics that extend beyond the AHI will be considered, with particular attention to the sleep-apnea-specific hypoxic burden, the sleep-apnea-specific heart rate response, and pulse wave amplitude drops (PWADs). Since the impact of treatment on cardiovascular parameters remains an important point of interest, the effects of different treatment modalities on cardiovascular changes will be investigated, including continuous positive airway pressure (CPAP), mandibular advancement devices (MADs), and hypoglossal nerve stimulation.

Eligibility Criteria

Inclusion Criteria: * AHI ≥ 15 events/hour, based on a recent (\

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07427589). StuddyBuddy aggregates publicly available trial information.