Validation of NAD+ Measurements for Human Clinical Studies

Conditions: Healthy Adults

Sex: All

Ages: 18 Years – 110 Years

Healthy volunteers: Yes

Phase: NA

Enrollment: 48

Sponsor: University of Pennsylvania

Location: Penn Medicine Philadelphia Pennsylvania

Summary

The purpose of this study is to determine nicotinamide adenine dinucleotide (NAD) levels in healthy adult subjects before and after supplementing with over-the counter nicotinamide riboside (NR) using magnetic resonance spectroscopy (MRS).

Eligibility Criteria

* Male or female age18-35 years or 70 years or older, healthy * if female reproductive potential, use of highly effective contraception (at least 1 month prior to screening and during study participation). * No known sensitivity to NR * No use of niacin, blood thinners or chemotherapy agents * HbA1c below 8.5% and not diabetec requiring insulin. * Not using/taking corticosteroids * No laboratory abnormalities indicating significant anemia, bleeding risk, kidney disease, or liver disease * No contraindication to MRI * Not Pregnant, lactating, or planning to become pregnant during participation * Not taking multivitamins or any over-the-counter supplements except calcium and vitamin D (any other supplements - discontinued 2 weeks prior to study participation). * not taking/ undergoing another investigational drug or other intervention within the past 30 days.

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07416786). StuddyBuddy aggregates publicly available trial information.