Sensory Stimulation as a Driver of Diet-induced Thermogenesis

This study aims to assess the influence of sensory stimulation on diet-induced energy expenditure by way of a clinical cross-over trial in 24 healthy participants either receiving a meal bolus with (orally) and without sensory stimulation (nasogastric-tube).

Inclusion Criteria: * healthy volunteers of any gender * BMI between 18-25 kg/m2 * age between 18 and 40 years Exclusion Criteria: * concomitant medication except for prescription free analgetics (paracetamol, NSAIDs) and oral contraceptives * clinically significant concomitant disease states (e.g. renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus), * allergy to local anaesthetic or any of the study meal ingredients * known or suspected non-compliance, drug or alcohol abuse * smoker / habitual tobacco use * habitual excessive alcohol consumption * inability to follow the procedures of the study * participation in another study with investigational drug within the 30 days preceding and during the present study * previous enrolment into the current study * enrolment of the investigator, his/her family members, employees and other dependent persons * uncontrolled hypo- or hyperthyroidism * pregnancy or lactation