Efficacy of 12-week Daytime Restricted Eating on Hepatic Steatosis of Obesity

The objective of this study is to demonstrate that an \< or equal to 8-hour time-restricted eating (i.e., fasting for at least 16 hours every day), not focusing on reducing caloric intake, reduces intra-hepatic fat in patients with obesity and Metabolic dysfunction-Associated Steatotic liver Disease (MASLD).

Inclusion Criteria: * Body mass index (BMI) between 30.0 and 49.9 kg/m2 * Age between 18 and 65 years (limits included) * Sedentary (light-intensity physical activity less than 1 hour per week) or moderately active (moderate exercise 1 to 2 hours per week). Self-declared criteria. * Weight stable for at least 3 months prior to the beginning of the study (gain or loss \ 12 hours per day * Subject who owns a smartphone with access to the internet, and agrees to use it in the study * Affiliation with French social security system or beneficiary from such system * Fibroscan® Controlled Attenuation Parameter (CAP) \> 300 dB/ms * Hepatitis B and C serologies negative (or showing past-infection or protective immunization) Exclusion Criteria: * Alcohol intake \> 20 g/day * Night-shift workers or rotating shift workers * Smoking * Patient with diabetes if HbA1c not at target (\