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NCT07363343
Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study
Conditions: Hypertension, Postpartum Preeclampsia
Sex: Female
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: NA
Enrollment: 200
Sponsor: The Cleveland Clinic
Location: Cleveland Clinic Cleveland Ohio
Summary
To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.
Eligibility Criteria
Inclusion Criteria:
* Postpartum women aged 18 years or older
* Clinical diagnosis of hypertensive disorder in pregnancy (gestational hypertension, chronic hypertension, preeclampsia with or without severe features)
* Taking Nifedipine 60 mg every 12 hours for blood pressure control
* Persistently elevated blood pressure at/above 140/90 mmHg in a 24-hour time period or have one or more severe range blood pressure at/above 160/110 mmHg requiring a second antihypertensive medication
* English speaking
Exclusion Criteria:
* Taking ≥2 antihypertensive agents during pregnancy
* Heart block
* Heart rate \120 beats per minute
* Heart failure
* Creatinine \>1.5 mg/dL
* Renal artery stenosis
* Active connective tissue disease
* Cerebrovascular accident
* Failed treatment or contraindications to nifedipine, enalapril or labetalol
Source: ClinicalTrials.gov (NCT07363343). StuddyBuddy aggregates publicly available trial information.