IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients

Conditions: Critical Illness, Intensive Care Patients, Critical Illness Requiring Intensive Care - Sepsis, Critical Illness Requiring Intensive Care - Acute Brain Injury, Critical Illness Requiring Intensive Care - Major Surgery, Critical Illness Requiring Intensive Care - Polytrauma

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Enrollment: 540

Sponsor: Assistance Publique - Hôpitaux de Paris

Location: AP-HP Laribosière Hospital, Anesthesia and Critical Care Departement Paris

Summary

This is a prospective observational physiopathological study aimed at evaluating the immunological and inflammatory determinants associated with the prognosis of patients admitted to intensive care units (ICU). The study will establish multidimensional models predicting one-year survival and the occurrence of nosocomial infections. Patients admitted to ICU undergo routine biological sampling. In addition to these, minimal supplementary samples will be collected for immunological and inflammatory biomarker analysis at admission, day 1, day 4, day 8, ICU discharge or day 28, and at 12 months. Additional samples may be taken during clinically significant events (nosocomial infections, complications).

Eligibility Criteria

Inclusion Criteria: * Age ≥ 18 years * Admission to ICU within 24 hours Exclusion Criteria: * Moribund patient (ECOG=4) * Legal protection (guardianship/curatorship) * Uninsured patients * Pre-existing immunosuppression (active/recent cancer, hematologic disease, autoimmune disease, organ transplant, HIV) * Pregnant or breastfeeding women * Participation in another interventional trial * Patients under AME

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07345169). StuddyBuddy aggregates publicly available trial information.