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NCT07319377
Evaluation of Safety and Efficacy of a Digital Therapeutic Device to Improve Strength in Sarcopenia (Sarc-DTx)
Conditions: Sarcopenia
Sex: All
Ages: 50 Years – 85 Years
Healthy volunteers: No
Phase: NA
Enrollment: 130
Sponsor: Exosystems
Location: Bucheon St. Mary's Hospital Bucheon-si
Summary
This clinical trial aims to demonstrate that the use of a digital therapeutic device (exoDTx) in patients with sarcopenia is superior to self-exercise in terms of muscle strength improvement and safety.
Eligibility Criteria
Inclusion Criteria
* Individuals diagnosed with sarcopenia according to both the European Working Group on Sarcopenia in Older People (EWGSOP) criteria and the Asian Working Group for Sarcopenia 2019 (AWGS 2019) criteria
* Individuals with reduced muscle strength, defined as at least one of the following:
* Handgrip strength \< 28 kg for men or \< 18 kg for women
* Five-times Sit-to-Stand Test time \> 12 seconds without arm support
* Individuals with reduced muscle mass, defined as at least one of the following:
* Skeletal Muscle Mass Index (SMI) \< 7.0 kg/m² for men or \< 5.4 kg/m² for women measured by DXA
* Skeletal Muscle Mass Index (SMI) \< 7.0 kg/m² for men or \< 5.7 kg/m² for women measured by BIA
* Individuals able to independently perform sit-to-stand movements
* Individuals with sufficient physical and cognitive capacity to participate in the exercise program
* Individuals able and willing to provide written informed consent
* Individuals able to operate a mobile phone independently or with assistance from a caregiver
Exclusion Criteria
* Individuals with cognitive impairment, defined as a Mini-Mental State Examination (MMSE) score \< 20, or those unable to participate due to cognitive decline
* Individuals with an implanted cardiac pacemaker or other implanted electronic medical device
* Individuals with uncontrolled cardiovascular disease despite appropriate medical management
* Individuals who have undergone lower-limb surgery within the past 6 months and are unable to ambulate independently
* Individuals with moderate-to-severe musculoskeletal pain or functional limitations that interfere with objective functional assessments
* Individuals with severe obesity, defined as a body mass index (BMI) \> 50 kg/m²
* Individuals currently receiving active cancer treatment or experiencing severe systemic frailty
* Individuals with hemiplegia that prevents participation in the prescribed exercise program
* Individuals who are anticipated by the investigator to be unable to complete the study procedures or follow-up assessments
* Individuals unable to understand or comply with study instructions provided in Korean
* Individuals considered unsuitable for study participation at the discretion of the investigator for any other reason
Source: ClinicalTrials.gov (NCT07319377). StuddyBuddy aggregates publicly available trial information.