Evaluation of the Association Between the Effects of Generalized Stage 3 and 4 Periodontitis on Arterial Stiffness and Cardiovascular Risk: the PAROCAR Study

Periodontal diseases are chronic inflammatory conditions affecting nearly half of the adult population and are associated with systemic inflammatory responses. Recent evidence suggests a possible link between severe periodontitis and cardiovascular diseases through shared inflammatory pathways. The PAROCAR study aims to evaluate the association between generalized periodontitis (stages 3 and 4, 2017 Chicago Classification) and arterial stiffness measured by pulse wave velocity (PWV), compared to matched controls without periodontitis, adjusted for conventional cardiovascular risk factors.

Inclusion Criteria: * Age 40-69 years * Minimum of 12 teeth (3 per quadrant) * Written informed consent Exposed group: generalized periodontitis stage 3 or 4 (Chicago 2017 Classification) Non-exposed group: healthy periodontium Exclusion Criteria: * Patients diagnosed with diabetes, * Patients diagnosed with hypertension or with a history of severe cardiovascular disease, * Patients diagnosed with familial hypercholesterolaemia, * Patients with a medical history or current condition that, in the investigator's opinion, is likely to interfere with the study results, * Patients with a BMI ≥ 30 kg/m², * Patients who have previously undergone periodontal treatment, * Patients who consume more than 2 units of alcohol per day, * Patients who refuse to participate in the study, * Minors and patients under the age of 40, * Adult patients under legal protection (guardianship, curatorship), * Patients deprived of their liberty, * Pregnant or breastfeeding women, * Patients not affiliated with a health insurance scheme (AME) * Patients already included in another interventional study