Sugammadex and Menstrual Cycle in Postoperative Nausea and Vomiting

This observational study aims to evaluate the relationship between menstrual cycle phases and the incidence of postoperative nausea and vomiting (PONV) in women of reproductive age undergoing septorhinoplasty surgery. The study's primary objective is to determine whether different phases of the menstrual cycle are associated with variations in PONV frequency. As a secondary objective, the relationship between menstrual phases, PONV incidence, and the use of sugammadex during anesthesia will be analyzed. No additional intervention will be applied beyond routine clinical practice; all data will be collected prospectively from anesthesia records and postoperative evaluations.

Inclusion Criteria: * Female sex * Age between 18 and 40 years * Regular menstrual cycle * Scheduled for ENT (ear, nose, and throat) surgery * Classified as ASA physical status I or II Exclusion Criteria: * Irregular menstrual cycle * Unknown date of last menstrual period * Receiving estrogen and/or progesterone supplementation * Pre-menopausal or menopausal status * Pregnant * Breastfeeding * Classified as ASA physical status III or IV * Apfel score ≥ 3 * History of drug allergy * Surgery duration exceeding 3 hours * Age \40 years