Wearable Focused Ultrasound Stimulation for Peripheral Nerve Pain Management

This study will evaluate the feasibility of a novel wearable focused ultrasound (FUS) device for peripheral nerve stimulation in healthy volunteers. The aim is to assess device operability, usability, tolerability, and physiological responses during standardized sensory tests. Each participant will complete nine \~1-hour study sessions across multiple days, including cold pressor and algometry tasks performed under baseline, sham, and active FUS conditions.

Inclusion Criteria: \- Healthy adults aged 20-40, willing and able to undergo FUS experiments. Exclusion Criteria: * Major physical illnesses. * Diagnosis of a cognitive disorder. * Cardiovascular conditions (e.g., high blood pressure, heart disease, or dysrhythmia), history of fainting or seizures, or history of frostbite. * Open cuts, sores, or bone fractures on the limb to be immersed in water, or a history of Raynaud's phenomenon. * Diagnosis of hypersensitivity or hyposensitivity to bodily sensations (temperature, vibrotactile, nociception). * Inability to provide informed consent for FUS stimulation.