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Completed
NCT07150442
The Effects of Platelet Rich Plasma Adjuvant to Type I/III Collagen Ratio, Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Pelvic Organ Prolapse Repair
Conditions: Pelvic Organ Prolapse Vaginal Surgery, Platelet Rich Plasma Injection
Sex: Female
Ages: 45 Years – 65 Years
Healthy volunteers: No
Phase: NA
Enrollment: 34
Sponsor: Andalas University
Location: Biomedical Science Doctoral Programme Faculty of Medicine Andalas University/ Urogynecology Division Obstetrics and Gynecology Department M Djamil Hospital Padang Padang West Sumatera
Summary
The goal of this clinical trial is to analyze the effect of Platelet Rich Plasma (PRP) Adjuvant To Type I/III Colagen Ratio, MMP-2 and MMP-9 in Pelvic Organ Prolapse Repair.
The main questions it aims to answer are:
Does the PRP Adjuvant affect type I/III Colagen Ratio, MMP-2 and MMP-9 in Pelvic Organ Prolapse Repair? Researchers will compare patient who undergo prolapse surgery with PRP adjuvant versus patient who undergo prolapse surgery without PRP adjuvant (placeebo)
Participants will:
Patient will undergo pelvic organ prolapse reconstrucion surgery and punch biopsy and injection of PRP will perform in anterior vaginal mucosa at Pubocervical area. The second biopsy will attempt in 8 weeks post operative. imunohistochemistry examination will be done to compare the type I/III Colagen Ratio, MMP-2 and MMP-9 before and after surgery.
Eligibility Criteria
Inclusion Criteria:
1. Patients with second-degree or higher pelvic organ prolapse
2. Postmenopausal pelvic organ prolapse patients
3. Patients with pelvic organ prolapse who will undergo surgery
4. Willingness to participate in the study
Exclusion Criteria:
1. Patients with gynecological malignancies
2. Patients with a history of collagen disease
3. Patients with blood disorders
Source: ClinicalTrials.gov (NCT07150442). StuddyBuddy aggregates publicly available trial information.
