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Completed
NCT07138677
Safty and Efficacy of MCI Network Guided TMS for Early Alzheimer's Disease: A Randomized, Double-blind Trial
Conditions: Alzheimer's Disease, Transcranial Magnetic Stimulation, Individualized Navigation
Sex: All
Ages: 45 Years – 85 Years
Healthy volunteers: No
Phase: NA
Enrollment: 40
Sponsor: Anhui Medical University
Location: Anhui Medical University Hefei Anhui
Summary
Estimate the safty and efficacy of personalized network neuronavigated transcranial magnetic stimulations in early Alzheimer's disease patients
Eligibility Criteria
Inclusion Criteria:
1. Subject diagnosed as either mild cognitive impairment due to AD or mild AD dementia based on National Institute on Aging-Alzheimer's Association criteria.
2. MMSE score 18-28.
3. CDR score 0.5-1.
4. On stable treatment with IAChE or memantine for at least 6 months.
5. Literate in Han Chinese.
Exclusion Criteria:
1. Recevied rTMS treatment in the past 3 months.
2. Depression or other psychiatric disorders.
3. History of head injury, stroke, epilepsy or other neurologic disease.
4. Organic brain defects on T1 or T2 images.
5. History of unexplained loss of consciousness.
6. Implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, or any implanted medical device that is incompatible with MRI.
7. Family history of medication refractory epilepsy.
8. History of substance abuse within the last 6 months.
Source: ClinicalTrials.gov (NCT07138677). StuddyBuddy aggregates publicly available trial information.
