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Recruiting NCT07093671

Mentalization Based Treatment (MBT) in Help Seeking Youths With a Clinical High-Risk Condition for Psychosis (CHR-P)

Conditions: Psychosis

Sex: All
Ages: 14 Years – 30 Years
Healthy volunteers: No
Phase: NA
Enrollment: 212
Sponsor: Marco Armando

Location: CHUV Lausanne

Summary

The primary objective of this study is to evaluate the efficacy of Mentalization-Based Treatment (MBT) combined with Need-Based Clinical Interventions (NBCI) compared to NBCI alone, on CHR-P diagnostic statuses and symptom expression (Hypothesis 1). Specifically, the investigator will assess diagnostic outcomes using a 3-level variable: transition to psychosis, CHR-P status quo, and remission out of CHR-P, as well as CHR-P symptom expression. The investigator hypothesize that: (1a) the experimental treatment (MBT + NBCI) will have a significant effect on diagnostic status (i.e. transition to psychosis) at the end of treatment and follow-up; (1b) the experimental treatment (MBT + NBCI) will significantly reduce the severity of psychotic symptoms at the end of treatment and follow-up.

Eligibility Criteria

Inclusion Criteria: * Patients aged 14-30 years with a CHR-P condition, as defined by the SIPS criteria * Patients who provide informed consent Exclusion Criteria: * Patients with a prior diagnosis of a psychotic disorder * Intellectual disability (IQ \< 70). * Patients whose psychotic symptoms are primarily induced by substance misuse. * Patients with significant language barriers * Parents/legal authority who do not provide informed consent (only minors) * Adult patient under guardianship Note: Comorbidities with other psychiatric disorders (e.g., Autism Spectrum Disorder, Personality Disorders) will not constitute an exclusion criterion.

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT07093671). StuddyBuddy aggregates publicly available trial information.