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Active Not Recruiting NCT07081022

JS203 Combination Regimens in B-Cell Non-Hodgkin's Lymphoma

Conditions: B-cell Non-Hodgkin's Lymphoma

Sex: All
Ages: 18 Years – 80 Years
Healthy volunteers: No
Phase: PHASE2
Enrollment: 180
Sponsor: Shanghai Junshi Bioscience Co., Ltd.

Location: Beijing Cancer Hospital Beijing Beijing Municipality

Summary

To evaluate the preliminary efficacy of JS203 combined with standard regimens in patients with B-cell Non-Hodgkin's lymphoma

Eligibility Criteria

Inclusion Criteria: Patients must meet all of the following inclusion criteria to be enrolled: * Age range: 18 to 80 years old (inclusive), both male and female are acceptable; * ECOG: 0-2; * B-cell non-Hodgkin's lymphoma expressing CD20 antigen that has been pathologically diagnosed; * At least one measurable lesion meeting the criteria specified in the Lugano 2014 response assessment; Acceptable organ function at screening; Exclusion Criteria: * A history of severe allergy to monoclonal antibody therapy (or recombinant antibody-related fusion protein); * Previously received CD20-CD3 bispecific antibody treatment; * Previous allogeneic hematopoietic stem cell transplantation; * Previous solid organ transplantation; * History of autoimmune diseases; * Patients with a history of macrophage activation syndrome (MAS)/ hemophagocytic lymphohistiocytosis (HLH); * Patients with a history of progressive multifocal leukoencephalopathy (PML); * A known or suspected history of CNS lymphoma (including primary or secondary); * There is pleural effusion, peritoneal effusion or pericardial effusion that requires treatment (such as puncture or drainage);

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Source: ClinicalTrials.gov (NCT07081022). StuddyBuddy aggregates publicly available trial information.