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NCT07081022
JS203 Combination Regimens in B-Cell Non-Hodgkin's Lymphoma
Conditions: B-cell Non-Hodgkin's Lymphoma
Sex: All
Ages: 18 Years – 80 Years
Healthy volunteers: No
Phase: PHASE2
Enrollment: 180
Sponsor: Shanghai Junshi Bioscience Co., Ltd.
Location: Beijing Cancer Hospital Beijing Beijing Municipality
Summary
To evaluate the preliminary efficacy of JS203 combined with standard regimens in patients with B-cell Non-Hodgkin's lymphoma
Eligibility Criteria
Inclusion Criteria:
Patients must meet all of the following inclusion criteria to be enrolled:
* Age range: 18 to 80 years old (inclusive), both male and female are acceptable;
* ECOG: 0-2;
* B-cell non-Hodgkin's lymphoma expressing CD20 antigen that has been pathologically diagnosed;
* At least one measurable lesion meeting the criteria specified in the Lugano 2014 response assessment; Acceptable organ function at screening;
Exclusion Criteria:
* A history of severe allergy to monoclonal antibody therapy (or recombinant antibody-related fusion protein);
* Previously received CD20-CD3 bispecific antibody treatment;
* Previous allogeneic hematopoietic stem cell transplantation;
* Previous solid organ transplantation;
* History of autoimmune diseases;
* Patients with a history of macrophage activation syndrome (MAS)/ hemophagocytic lymphohistiocytosis (HLH);
* Patients with a history of progressive multifocal leukoencephalopathy (PML);
* A known or suspected history of CNS lymphoma (including primary or secondary);
* There is pleural effusion, peritoneal effusion or pericardial effusion that requires treatment (such as puncture or drainage);
Source: ClinicalTrials.gov (NCT07081022). StuddyBuddy aggregates publicly available trial information.