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NCT07080970
Observational Study on APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions
Conditions: Acute Myeloid Leukemia, NPM1 Mutation
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Enrollment: 220
Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto
Location: SOD Ematologia, Università di Firenze, AOU Careggi Florence
Summary
This is a multicenter observational study with a retrospective and a prospective cohort investigating clinically and biologically the APL-like subset as a potential predictor of coagulopathy and susceptibility to early vascular events.
Eligibility Criteria
Inclusion Criteria:
* Patients with de novo AML, untreated, newly diagnosed, according to WHO/ICC 2022 criteria from January 2015 onwards.
* Presence of NPM1 mutation.
* Availability of immunophenotypic characterization at diagnosis
* Age \>= 18 years
* Signed written informed consent according to ICH/EU/GCP and national local laws (if applicable)
Exclusion Criteria:
* No specific exclusion criteria are provided once eligibility criteria are met.
Source: ClinicalTrials.gov (NCT07080970). StuddyBuddy aggregates publicly available trial information.
