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NCT07076641
Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia
Conditions: Digestive System Disease, Surgery
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: PHASE3
Enrollment: 76
Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche
Location: Hôpital Privé Jean Mermoz Lyon
Summary
The purpose of this study is to evaluate the superiority of IV lidocaine combined with morphine spinal anesthesia versus placebo combined with morphine spinal anesthesia, in reducing postoperative morphine consumption at 48 hours, in patients undergoing major digestive or abdominal surgery by laparotomy.
Eligibility Criteria
Inclusion Criteria:
* Age ≥ 18 years;
* Major digestive or abdominal surgery (pancreatic, hepatic, colorectal, gynecological, esophageal, gastric, duodenal, small intestine...);
* Scheduled surgery;
* Laparotomy;
* Patient in agreement with morphine rachi anesthesia;
* Social security affiliation;
* Signed informed consent.
Exclusion Criteria:
* Emergency surgery;
* Contraindication to non-steroidal anti-inflammatory drugs: history of gastro duodenal ulcer, renal failure from stage 3 A or higher;
* History of bradycardia and/or known conduction disorder (atrioventricular block) / Pacemaker ;
* Unstable coronary ;
* Myocardial infarction \
Source: ClinicalTrials.gov (NCT07076641). StuddyBuddy aggregates publicly available trial information.
