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NCT07067736
Cefazolin Antibiotic Prophylaxis in Ventricular Shunt Surgery: Determination of Cerebrospinal Fluid Concentration During Valve Implantation
Conditions: Hydrocephaly, CSF Shunts, Antibiotic Prophylaxis
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: NA
Enrollment: 15
Sponsor: University Hospital, Strasbourg, France
Location: Hôpitaux Universitaires de Strasbourg Strasbourg
Summary
The objective is to determine the concentration of cefazolin in the cerebrospinal fluid after a recommended antiobiotic prophylaxis by 2g of cefazolin. Our main hypothesis is that the concentration is insufficient to protect the valve from infections.
The secondary objective is to compare our results to known pharmacokinetic models of cefazolin diffusion in the literature. If differences are found we would like to search clinical features that could explain it.
Eligibility Criteria
Inclusion Criteria:
Age \>18 years and programmed for a ventricular shunt surgery at the Hautepierre university hospital in Strasbourg.
Exclusion Criteria:
* Age \
Source: ClinicalTrials.gov (NCT07067736). StuddyBuddy aggregates publicly available trial information.
