Effect of Aerobic Exercise on Biomarkers in Depression

This study aims to investigate changes in the levels of biomarkers (IGF-1, FGF2, and EGF) involved in neuron development in patients diagnosed with major depression through the effects of breathing exercises and aerobic exercise, as well as to examine the levels of biomarkers (TNF-α, IL-6, and IL-1) and oxidative stress (TAS, TOS, MDA, and F2-isoprostane) that are thought to play a role in the pathophysiology of depression.

Inclusion Criteria: * Individuals who volunteer to participate in the study, * Between the ages of 18 and 40, * Have been diagnosed with clinical depression by a psychiatrist according to DSM-5 criteria Exclusion Criteria: * Individuals with chronic conditions accompanying depression, * Those with walking difficulties * Those with respiratory system disorders