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Recruiting
NCT07010250
Epithelial Dysmetabolism and Renal Fibrosis in ANCA Vasculitis
Conditions: ANCA Associated Vasculitis, Extramembranous Glomerulopathy, Nephrotic Syndrome, Minimal Change, Interstitial Nephritis, IgA Nephropathy, Segmental Hyalinosis, Diabetic Nephropathies
Sex: All
Ages: 18 Years – 90 Years
Healthy volunteers: No
Enrollment: 146
Sponsor: Assistance Publique - Hôpitaux de Paris
Location: Georges-Pompidou European Hospital, AP-HP Paris
Summary
The project is to explore in humans the hypothesis of the link between the alteration of tubulo-interstitial metabolism and the rate of deterioration of renal function by comparing various nephropathies.
Eligibility Criteria
Inclusion Criteria:
* Patients with an indication for initial diagnostic PBR on native kidney
* 18 ans ≥ Age ≤ 90 ans
* Affiliation to french health insurance
* Patient having given consent
For the ANCA vasculitis group:
• Diagnosis of ANCA vasculitis retained on renal biopsy with ANCA anti-proteinase 3 (PR3) or ANCA anti-myeloperoxidase (MPO)
For the control groups:
• Diagnosis retained after the renal biopsy
* Interstitial Nephritis
* Or glomerular nephropathy such as minimal change nephropathy
* Or Segmental hyalinosis in itscollapsing form
* Or Extramembranous Glomerulopathy,
* Or glomerulopathy with mesangial IgA deposits
* Or diabetic nephropathy.
Exclusion Criteria:
* Kidney transplant patient
* Patient on dialysis (hemodialysis or peritoneal dialysis)
* Patient under legal protection, guardianship or curatorship
* Pregnancy or breastfeeding
* Enrollement in an interventional study except studies relating to ANCA vasculitis and nephropathy with mesangial IgA deposits.
Source: ClinicalTrials.gov (NCT07010250). StuddyBuddy aggregates publicly available trial information.
