Trial of Pistachio Consumption in Older Adults

The goal of this study is to evaluate whether a pistachio-enriched diet leads to changes in cognitive function, cardiometabolic risk factors, and life satisfaction in older adults over a 6-month period.

Inclusion Criteria: 1. Active participant in COSMOS 2. Current age 65 to 80 years 3. Does not reside in the states of Arizona, Hawaii, or Wyoming (since Quest Diagnostics does not have locations in these states) Exclusion Criteria: 1. Tree nut allergy 2. Current intake of pistachios, peanuts, walnuts, or other nuts \>1 serving/week 3. Diagnosis of Alzheimer's disease or any other type of dementia 4. Diagnosis of cancer or CVD (MI, stroke, CABG, PTCA, or stent) within last 12 months 5. Changes in the dose or number of anti-hypertensive, lipid-lowering, or diabetic medications over the past 3 months prior to randomization 6. Does not own a smartphone or tablet 7. Unable or unwilling to abstain from pistachio intake for 6 months 8. Unable or unwilling to limit nut consumption to ≤1 serving/week for 6 months 9. Unable or unwilling to complete online questionnaires and cognitive assessments 10. Unable or unwilling to travel to a local Quest site for biospecimen collection 11. Unable or unwilling to provide consent to participate in the trial 12. Failure to complete the baseline Life Satisfaction Questionnaire 13. Failure to complete the baseline cognitive assessments 14. Failure to complete the baseline biospecimen collection