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NCT06974838
Explore the Therapeutic Effect of Theta Burst Stimulation on Emotion Regulation in Autism With Minimally Verbal Ability or Intellectual Disability
Conditions: Autism Spectrum Disorder, Minimally Verbal Ability, Intellectual Disability
Sex: All
Ages: 8 Years – 30 Years
Healthy volunteers: No
Phase: NA
Enrollment: 60
Sponsor: Chang Gung Memorial Hospital
Location: Chang Gung Memorial Hospital Taoyuan
Summary
The investigator would like to investigate the impact of theta-burst stimulation over left DLPFC in autism with minimally verbal ability or intellectual disability
Eligibility Criteria
Inclusion Criteria:
* Diagnosis of autism spectrum disorder, confirmed by DSM-5.
* Individuals with minimal verbal ability or intellectual disability (FSIQ \< 70).
Exclusion Criteria:
* Current or past severe neurological disorders, such as epilepsy, or significant visual or hearing impairments.
* Current or past severe systemic diseases, such as cardiovascular disease, diabetes, or multiple sclerosis.
* History of severe brain injury.
* Presence of implanted metal devices, such as a pacemaker or medication pump.
* Current or past severe psychiatric disorders, such as schizophrenia, bipolar disorder, or major depressive disorder.
* Pregnancy.
* Significant brain abnormalities, such as intracranial space-occupying lesions.
* Family history of epilepsy.
* History of febrile seizures.
* Concurrent use of medications that increase the risk of seizures.
* Sleep disorders during rTMS procedures.
* Skin lesions or trauma at the stimulation site.
* Deemed ineligible by the principal investigator (PI).
* Participation in another clinical trial within the past month.
* Suicidal ideation or suicide attempts within the past year.
Source: ClinicalTrials.gov (NCT06974838). StuddyBuddy aggregates publicly available trial information.