To Evaluate the Influence of (LUA Probiotics) on Uric Acid

This study aims to investigate the efficacy of the lactic acid bacteria "LUA probiotics" in reducing serum uric acid levels. The use of health supplements prior to the onset of gout symptoms is proposed as a preventive strategy to mitigate the development of gout and to reduce the subsequent reliance on long-term pharmacological treatments. Hyperuricemia is the presence of abnormally high levels of uric acid in the blood serum. Long-term hyperuricemia is a major factor in causing gout. In addition, hyperuricemia is associated with many diseases. Therefore, the prevention and treatment of hyperuricemia has gradually attracted attention. In recent years, studies have pointed out that whether from cell experiments or animal experiments, lactic acid bacteria (LAB) have the effect of lowering uric acid. However, there is a lack of rigorous clinical observational studies to further explore whether lactic acid bacteria really have the effect of lowering uric acid. This product "LUA Probiotics" is a probiotic developed and produced by the Longtan Branch of Grape King Biotechnology Co., Ltd. Its main ingredients include Lactobacillus reuteri (Lactobacillus reuteri), β-carotene, silicon dioxide and magnesium stearate. This product is not yet commercially available.

Inclusion Criteria: 1. Collect 20 people, both male and female, aged 20 or above. 2. Be conscious, willing to participate in the clinical observational research project, and complete the signed written consent form. 3. Patients with hyperuricemia (uric acid level above 7.5 mg/dL) who have not taken uric acid-lowering drugs, and patients with gout who have not taken uric acid-lowering drugs, regardless of gender. Exclusion Criteria: 1. Patients diagnosed by a physician as suffering from a major injury or illness listed by the National Health Insurance Administration. 2. Pregnant women or women who plan to become pregnant within six months. 3. Patients with abnormal liver function (AST, ALT greater than 2 times the upper limit of normal). 4. Patients with abnormal renal function (serum creatinine \> 1.5 mg/dL). 5. Patients with gastrointestinal dysfunction (surgery, frequent diarrhea). 6. Those who must continue to take antibiotics, histamine-2 antagonists, proton pump inhibitors, antioxidants, probiotics, laxatives and other drugs. 7. Patients with serious complications such as stroke, myocardial infarction, or major trauma or surgery in the past six months. 8. People who are allergic to Lactobacillus. 9. Subjects who are unable to exercise their right to consent on their own. 10. Those who have irregular eating habits and are unable to cooperate with the plan implementation. 11. Those who have poor compliance with doctor's orders.