Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis. A secondary aim is to determine whether patients experience any more measurable side effects than those receiving sham treatments.

Inclusion Criteria: * • patient's primary care provider is at Mayo Clinic in Rochester, MN * age 50-100 years * ICOAP pain scale A1 at least moderate intensity or B6 at least moderate intensity * diagnosed with primary knee OA ICD-10 codes M17.x o You have not had recurrent episodes of sudden onset of warmth, redness, or swelling of the affected knee * physical exam findings of medial or lateral joint line tenderness on palpation that is in the same location as the knee pain. * absence of primary knee pain in the pes anserine or hamstring or gastrocnemius, quadriceps, or patellar tendons on exam. * radiographic Kellgren-Lawrence grade 2-3 on 4-view knee x-rays taken within the last year ability to complete surveys electronically by email Exclusion Criteria: * • Kellgren-Lawrence grade 1 or 4 * pregnancy or women 54 years and younger with potential for pregnancy (if they or their partner have not had tubal ligation, hysterectomy, or vasectomy) * history of ipsilateral intraarticular knee surgery * use of injected corticosteroids within 3 months or hyaluronans within 6 months or within 1 month if there was no sustained improvement post-injection of either corticosteroid or hyaluronan. * history of trauma to this knee in the last year that clearly caused the pain now present * history of RA, gout, pseudogout, hemarthroses (eg, hemophilic arthropathy) or other inflammatory arthritis involving this knee * history of symptomatic hip OA * history of psychosis, personality disorder, uncontrolled affective disorder * history of fibromyalgia * malignancy requiring active treatment current regular use of opiate analgesics, PRP, or acupuncture for the knees