Clinical Exploration of NEUROMARK System in Participants With Chronic Migraine

Clinical exploration of NEUROMARK System in Participants with Chronic Migraine

Inclusion Criteria: Participant Must: * Be ≥18 years of age. * Have Chronic Migraine * Be willing and able to comply with all study elements, as indicated by written informed consent. Exclusion Criteria: Participant Must Not: * Have diagnosis or history of complicated migraine, basilar migraine, ophthalmoplegic migraine, hemiplegic migraine, or migrainous infarction. * Progressive neurologic disorder other than migraine. * Have clinically significant anatomic obstruction that in the investigator's opinion limit access to the posterior nose, including but not limited to severe septal deviation or perforation, nasal polyps, and/or sinonasal tumor. * Have plans to (or otherwise anticipates the need to) undergo an ENT procedure concurrently or during study. * Have had previous sinus or nasal surgery within 6 months of study enrollment. * Have previously undergone radiofrequency, cryotherapy, or other surgical interventions for rhinitis. * Have started a new migraine medication regimen within 3 months of study enrollment that, according to the manufacturer's labeling, has not yet stabilized. * Have an acute nasal or sinus infection. * Have nasal mucosal erosion/ulceration. * Be on prescribed anticoagulants (eg, warfarin, Plavix) or 325 mg aspirin that cannot be held for an appropriate time before the procedure. * Have hemophilia. * Have a history of chronic epistaxis or experienced a significant epistaxis event (defined as epistaxis requiring medical intervention) in the past 3 months. * Have numbness of the soft palate, excessive dry eye, excessive dry nose, or other indication of neuro/nerve compromise in the sinonasal cavity. * Have had previous head and/or neck irradiation. * Be pregnant. * Have a physical, neurological, medical, psychiatric condition or situation that, in the investigator's opinion, puts the participant at risk, could confound the study results, or may interfere significantly with the participant's participation in the study. * Be participating in another clinical research study.