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Recruiting
NCT06824415
Sleep TMS for Depression
Conditions: Major Depression, Sleep
Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 55
Sponsor: Stanford University
Location: Stanford University Stanford California
Summary
The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.
Eligibility Criteria
Inclusion Criteria:
* Adults ages 18-65 years
* Current Major Depressive Disorder (MDD) diagnosis
* Failed ≥1 antidepressant medication
* Moderate-to-severe depression
* Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment
* Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS/MRI contraindications.
Exclusion Criteria:
* Intellectual disability
* Significant head injury/neurological disorder
* Pregnancy or postpartum
* TMS/MRI contraindications
* Active substance use/suicidal ideation
Source: ClinicalTrials.gov (NCT06824415). StuddyBuddy aggregates publicly available trial information.
