Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients With Brain Lesions.

Neurovascular uncoupling (NVU) represents a major source of potential bias for the identification of eloquent brain regions through activation procedures in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). Same region shows proper pattern in glucose metabolism in victiny of brain lesions, investigated with positron emitted tomography with radiolabeled glucose (PET-FDG) This research project aims at investigating the mechanisms of NVU by using a multimodal noninvasive imaging approach in neurosurgical patients.

Inclusion Criteria: * patients in the study include prior imaging showing a potentially resectable intra-cerebral mass lesion. Patient has to be included before surgery, chemotherapy and radiation Exclusion Criteria: * previous brain surgery * respiratory failure * Asthma * Claustrophobia * Previous adverse reaction to gadovist (contrast agent) * Pregnancy and Breath feeding * Diabetes (type I and II)