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NCT06768528
Association Between GalectiN-3 and pOSt-operative atrIal Fibrillation After Coronary Artery bypaSs Graft
Conditions: Post-operative Atrial Fibrillation, Cardiovascular Diseases, Post-pericardiotomy Syndrome
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Enrollment: 90
Sponsor: University of Sao Paulo General Hospital
Location: Instituto do Coração - Hospital das Clínicas - Faculdade de Medicina da Universidade de São Paulo São Paulo São Paulo
Summary
The goal of this observational study is to test the association between high levels of Galectin-3 and the occurrence of post-operative atrial fibrillation after isolated coronary artery bypass grafting (CABG). The main question\[s\] it aims to answer are:
* Is Galectin-3 an accurate biomarker to predict higher risk of developing post-operative atrial fibrillation?
* Are high levels of Galectin-3 associated to other post-operative complications and major adverse cardiovascular events? Participants will be enrolled during pre-operative evaluation and a peripheral blood sample collection will be performed in the 24h before CABG. Participants will then be followed for a period of 12 months (daily during hospitalization and 3 appointments after hospital discharge) to determine whether patients with higher levels of Galectin-3 will have worse outcomes.
Eligibility Criteria
Inclusion Criteria:
* Patients undergoing coronary artery bypass graft surgery
Exclusion Criteria:
* Inability to sign the free and informed consent form
* Renal dysfunction with estimated glomerular filtration rate less than 30ml / min / 1.73m² or dialysis therapy
* Moderate to severe left ventricular dysfunction (ejection fraction \< 40%)
* Patients with previous atrial fibrillation
* Pregnancy
* Concomitant valve surgery
Source: ClinicalTrials.gov (NCT06768528). StuddyBuddy aggregates publicly available trial information.