A Study of Probiotics in IgA Nephropathy

IgA nephropathy (IgAN) occurs when a specific form of the IgA antibody lodges on the kidneys and causes damage, which may lead to kidney failure. This form of IgA is likely to come from the gut and the upper airways. Recent studies have shown that the bacteria that live in these areas may be different in IgAN. We think that the interaction between these and the immune system triggers production of the IgA that leads to kidney damage. We will examine these bacteria in detail, and test whether a probiotic can alter this favorably, and reduce harmful forms of IgA production in IgAN.

Inclusion Criteria: 1. Biopsy-proven IgAN 2. Age 18 years or older 3. Able and willing to give informed consent 4. Sufficient understanding of English to understand the patient information sheet and complete questionnaires 5. No change in medications for 6 weeks up to the Baseline visit 6. Stable diet (e.g. not a change to elimination, reduction, vegan or vegetarian diet) for 30-days prior to the baseline visit and during the study Exclusion Criteria: 1. Aged \