Multimodal Differences in Effort-based Decision-Making in De... | Clinical Trial | StuddyBuddy@endsection Multimodal Differences in Effort-based Decision-Making in Depression
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Not Yet Recruiting NCT06648460

Multimodal Differences in Effort-based Decision-Making in Depression

Conditions: Depression, Anhedonia

Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 90
Sponsor: Georgia Institute of Technology

Location: Georgia Tech Manufacturing Institute Atlanta Georgia

Summary

Major depressive disorder (MDD) is a serious condition that causes long-term symptoms such as feeling sad, losing interest in activities, and having thoughts of self-harm. Difficulty in making an effort is a key factor in functional impairment. Current methods to evaluate this difficulty use clinical assessments and computer-based tasks, but there is a gap between the measurements and real-life behavior. To address this, the study team proposes creating an instrumented behavioral test, HORMES, to objectively assess reduced motivation during everyday activities and measure physiological responses. The study will examine differences in brain activity, autonomic system function, and metabolic energy expenditure in patients with major depression during a decision-making task that involves physical effort.

Eligibility Criteria

Inclusion Criteria: * Matched control group * 18-65 years old * Able-bodied * Fluent in English * Able to give written and verbal informed consent to the proposed experiment * Able to comprehend the study procedure, potential risks, and benefits * Group with depression * Diagnosed with major depression * Quick Inventory of Depression Symptomology (QIDS) score \> 5 * 18-65 years old * Able-bodied * Fluent in English * Able to give written and verbal informed consent to the proposed experiment * Able to comprehend the study procedure, potential risks, and benefits Exclusion Criteria: * Matched control group * Current diagnosed psychiatric disorder (e.g., anxiety, depression, bipolar disorder) * Current pregnancy * BMI \> 35 * Currently on antipsychotics * Group with depression * Diagnosed with psychotic symptoms * Diagnosed with other neurological or psychiatric disorders * Current pregnancy * BMI \> 35 * Currently on antipsychotics

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT06648460). StuddyBuddy aggregates publicly available trial information.