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NCT06641791
Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer
Conditions: Advanced Head and Neck Cancer
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: PHASE3
Enrollment: 196
Sponsor: Canadian Cancer Trials Group
Location: Arthur J.E. Child Comprehensive Cancer Centre Calgary Alberta
Summary
This study is being done to answer the following question: Does stereotactic body radiation therapy (SBRT) provide better cancer control compared to standard radiation therapy (RT) for those with advanced head and neck cancer?
Eligibility Criteria
Inclusion Criteria:
* Histologically confirmed mucosal squamous cell carcinoma (SCC) of the head and neck arising from at least one of the following sites: oro/hypopharynx, oral cavity, supraglottic larynx, maxillary sinus, nasal cavity, or unknown primary
* Stages TX or T0-T4/N0-N3
* Must be considered unfit for curative intent RT as determined by the treating oncologist(s)
* Geriatric 8 score \8 cm (in one dimension).
* \> 2 nodal levels (Level 1a/b not counted); retropharyngeal lymph nodes (where the closest edge is \< 2cm from the closest edge of CTV (primary or nodal) will not be considered as a different level). Note: a single lymph node mass that spans 2 levels will be considered as 1 level.
* Gross tumour poorly visualized on CT/MRI.
* Definitive radiological or clinically evident distant metastases.
* Scleroderma/CREST syndrome.
Source: ClinicalTrials.gov (NCT06641791). StuddyBuddy aggregates publicly available trial information.