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Active Not Recruiting
NCT06585462
Single and Multiple Ascending Dose Study of AMG 513 in Participants With Obesity
Conditions: Cardiometabolic Disease
Sex: All
Ages: 18 Years – 65 Years
Healthy volunteers: Yes
Phase: PHASE1
Enrollment: 82
Sponsor: Amgen
Location: Anaheim Clinical Trials Anaheim California
Summary
The primary objective of this study is to assess the safety and tolerability of AMG 513 after single and multiple doses.
Eligibility Criteria
Inclusion Criteria:
* Participants in the study will be males and females 18 to 65 years of age at the time of signing the informed consent with a body mass index (BMI) of 30.0 kg/m\^2 to 40.0 kg/m\^2 for Part A and BMI of 27.0 kg/m\^2 to 40.0 kg/m\^2 for Part B.
* Females enrolled must be of non-childbearing potential.
Exclusion Criteria:
* History and/or clinical evidence of diabetes mellitus, including hemoglobin A1c ≥ 6.5% and/or a fasting glucose of ≥ 126 mg/dL (7 mmol/L) at screening.
* Triglycerides ≥ 5.65 mmol/L (i.e., 500 mg/dL) at screening.
Source: ClinicalTrials.gov (NCT06585462). StuddyBuddy aggregates publicly available trial information.
