Slow Multiallergen Oral Immunotherapy in Young Children

The aim is to study whether a multiallergen oral immunotherapy (OIT) strategy with slow up-dosing and low treatment dose against food allergy in young children (0.5-3 years) is safe and effective, a method to cure food allergy and to prevent the development of new food allergies. Clinical randomized controlled (1:1) blinded interventional trial (RCT) with 2 intervention arms (group A and B). Among 80 children reacting at the multiallergen food challenge, 40 children will be randomized to receive OIT (oral immunotherapy) with multiallergen powder with a final dose of approximately 200 mg protein of each included food (egg, milk, soy, wheat, walnut, peanut, hazelnut, cashew, almond, lentils)(group A) or to receive placebo powder (gluten-free oatmeal) (group B). A sub-analysis will be performed of the children not reacting to the baseline challenge, who will be randomized to eat a low dose of the multiallergen powder (group C) or placebo powder (gluten-free oatmeal) (group D) and no specific advice.

Inclusion Criteria: * 0.5-3 years old at inclusion with IgE (\>0.1 kUA/l) against at least one allergen (wheat, lentils, egg, milk, soy, walnut, hazelnut, peanut, almond, cashew). * Written consent for participation in the study for both guardians. * 80 children (group A and B) also need a positive baseline food challenge. * Children with a negative food challenge (group C and D) (number not determined) do not react at the baseline challenge. Exclusion Criteria: * other serious illness * previous life-threatening anaphylaxis (intensive care) * eosinophilic esophagitis * eosinophilic gastrointestinal disease * severe chronic gastroesophageal reflux disease * unclear recurrent GI complaints * low body weight \