MRD Detection by NGS in Pediatric T-ALL

This retrospective analysis aims to investigate pediatric patients with T cell acute lymphoblastic leukemia who were detected for minimal residual disease (MRD) using next-generation sequencing (NGS). The study will utilize second-generation sequencing technology to analyze the rearrangement of the T cell receptor (TCR) genes in these patients. Patients will be stratified based on NGS-MRD levels, and the relationship between NGS MRD and Event-Free Survival (EFS) will be evaluated.

Inclusion Criteria: * Children with newly diagnosed T-ALL who undergone NGS of T-cell receptors Exclusion Criteria: * T-ALL patients who have not undergone high-throughput sequencing. * T-ALL Patients without traceable significant clones.