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NCT06446765
Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder
Conditions: Borderline Personality Disorder
Sex: All
Ages: 18 Years – 60 Years
Healthy volunteers: No
Phase: PHASE2
Enrollment: 150
Sponsor: Yale University
Location: Connecticut Mental Health Center New Haven Connecticut
Summary
The purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fMRI) neurofeedback (mbNF) to increase the benefits of evidence-based psychotherapy for adults with Borderline Personality Disorder (BPD).
Eligibility Criteria
Inclusion criteria:
* age 18-60,
* be able to provide written informed consent,
* meet criteria for BPD on semi-structured clinical interview,
* able to plan to keep any prescribed medications and psychotherapy constant during the study
* fluent in English.
Exclusion criteria:
* current DBT psychotherapy outside the study
* lifetime primary psychotic disorder
* manic episode in the last one year
* developmental disorder (e.g. autism)
* history of learning disorder
* severe substance use disorder in the last 3 months
* active suicidal ideation with intent or plan in the past 3 months
* history of major medical or neurologic disorder
* MRI contraindications, including pregnancy
* poor performance on reading task (WRAT \> 11 errors)
* newly prescribed medications in the past 8 weeks
* daytime sedating medications (e.g. benzodiazepines, opiates, sedating neuroleptics)
* any scheduled daily benzodiazepines
* change in psychotherapy type or frequency in the past 12 weeks.
* At the discretion of the study PI
Eligibility will be determined by study personnel.
Source: ClinicalTrials.gov (NCT06446765). StuddyBuddy aggregates publicly available trial information.